Friday, February 5, 2016

Whatever Happened to Rotavirus?

We are in the midst of what used to be Rotavirus season. Rotavirus is a viral intestinal infection which causes fever, vomiting, and diarrhea and generally lasts 3-8 days. In some cases, it can lead to dehydration and hospitalization, particularly in infants.

In the “old days,” meaning before 2006, it was not unusual for us to have several infants with Rotavirus admitted to the hospital at the same time at this time of year. Rotavirus was part of the reason that our pediatric ward was often full in the winter, sometimes causing our patients to overflow onto the adjacent adult ward. We dealt with Rotavirus so often that the nurses on the pediatric ward could usually predict a positive test for it before we had the results based on the smell of the stool. In contrast, that same pediatric ward now rarely houses more than a couple of patients at a time, though the decrease is certainly not due only to fewer cases of Rotavirus.

The difference is that we now have an oral vaccine for Rotavirus that is given at two, four, and six months of age. Just two years after introduction of this vaccine, there was an 85% reduction in ER visits and hospitalizations due to Rotavirus nationwide.
Prior to the currently available vaccines, there was another Rotavirus vaccine on the market. It was quickly discovered that there was a small increase in cases of intussusception, a type of intestinal obstruction, in children who had received the vaccine and it was quickly withdrawn from the market.

The currently available vaccines have been watched closely for this same association and no increased risk of intussusception has been found. The successful reduction of Rotavirus infections is evidence for the efficacy of the vaccine as well as the mechanisms in place for detecting adverse reactions to immunizations.